Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions

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Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions.

Nitric oxide (NO), produced by nitric oxide synthases (NOS enzymes), regulates multiple physiological functions in animals. NO exerts its effects by binding to iron (Fe) of heme groups (exemplified by the activation of soluble guanylyl cyclase) and by S-nitrosylation of proteins - and it is metabolized to nitrite and nitrate. Nitrite is used as a marker for NOS activity but it is also a NO dono...

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The respiration of Cancer pagurus under normoxic conditions and its respiratory responses to hypoxia are described. Respiration of quiescent crabs is characterized by a rhythmic pattern of ventilation and cardiac activity in which periods of apnoea and bradycardia of approximately 5 min duration alternate with longer periods of active ventilation and cardiac activity. The significance of this r...

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Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation.

During nitric oxide (NO) inhalation therapy, NO combines with deoxyhemoglobin to form nitrosyl hemoglobin (HbNO). We used electron spin resonance (ESR) spectroscopy to measure HbNO in arterial and mixed venous blood of normoxic and hypoxic sheep during NO inhalation. Our aim was to quantitatively measure HbNO levels in the blood during NO inhalation, because large amounts of HbNO reduce the oxy...

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Induction of nitric oxide synthase activity in pulmonary arteries from normoxic and chronically hypoxic rats.

Chronic hypoxia has recently been shown to upregulate inducible nitric oxide synthase (iNOS) gene expression in rat lung. In the present study, we questioned whether induction of NO synthesis could alter the reactivity of pulmonary arteries (PA) from chronically hypoxic (CH) rats. Dose-response curves to phenylephrine (PE) 10(-9) to 5 x 10(-6) M) were examined in PA rings as well as response to...

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Association between tobacco smoke and serum nitric oxide metabolites concentration

Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration. Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Gl...

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ژورنال

عنوان ژورنال: Journal of Experimental Biology

سال: 2010

ISSN: 1477-9145,0022-0949

DOI: 10.1242/jeb.048140